ZYMOX PLUS Advanced Otic Enzymatic Solution Hydrocortisone Free, Authentic Product Made in the USA

Contains a patented combination of enzymes to provide relief of persistent or recurring ear irritations and promote healthy ears. Advanced Formula ZYMOX Otic Plus 1% Hydrocortisone features increased potency of the patented LP3 Enzyme System to aid in removing ear exudate PLUS four additional biofilm-reducing enzymes formulated to destroy the hard-to-penetrate biofilm and the addition of 1% Hydrocortisone to reduce itching due to inflammation, dermatitis, and other minor skin irritations.  This advanced enzyme technology makes caring for your pet’s ears easy with reduced touching of sensitive ears.This product contains 1% hydrocortisone and is not for use on pregnant or lactating females.Made in the USA.UsesResistant otitisAntibacterial, antifungal, anti-yeastAntibiofilm technologyItch reliefIrritated or inflamed earsRemoval of ear exudatePromotes healthy earsFor dogs and catsFor pets who swimPets who live in moist or hot environmentsFeaturesSoothingNon-toxicNo PRE-CLEANING of the earFear-free ear careEasy, once daily applicationNo antibioticsAvailable sizes:  1.25 ozManaging Bacterial ResistanceBiofilm producing infections are 10 to 100x more resistant to the effects of antimicrobial agentsWhat is Biofilm?Biofilm is an ill-defined mix of polysaccharides, nucleic acids and proteins encased in a slimy matrix created by microorganisms to house DNA. Biofilm is the believed to be a culprit for antibiotic resistance and the reason many otitis cases are persistent or recurring.  Due to incomplete killing of cells, bacteria can remain hidden in a complex biofilm even after the infection appears to be resolved, patiently waiting for ideal conditions to multiply and re-infect.How Advanced Formula ZYMOX PLUS Otic WorksThe Advanced Formula ZYMOX PLUS features the patented LP3 Enzyme System PLUS four additional enzymes.  The combination of mutanase, dextranase, cellulase, and betagluconase work to attack the complex biolfilm structure, prevent adhesion and metabolize its components.  When combined with the antimicrobial LP3 Enzyme System, the results are antibacterial and antifungal along with effective biofilm removal.Mutanase can exhibit diverse action pattern but fundamentally degrades ẞ-1, 3-glucan to glucose, making it water soluble.Dextranase is an enzyme which catalyzes the endohydrolysis of 1,6-a-glucosidic linkages in dextran resulting in damage to the biofilm.Cellulase is critical to an antibiofilm enzyme preparation, as cellulose is found in most biofilms. Cellulase has been shown to significantly reduce biofilm formation by the pathogen Pseudomonas aeruginosa.Beta glucanase is another important antibiofilm component that provides powerful anticandidal biofilm activity by lysing the glucans that are common in candida biofilms and compose up to 60% of fungal cell walls. Beta-glucan secreted by candida cells within biofilms significantly increase the organism’s resistance to antifungals and enzymatic breakdown of the beta-glucan can make candida more susceptible to destruction.

Highly effective in the management of acute and chronic otitis due to bacterial, fungal or yeast infections without antibiotics.  The powerful enzymatic action of the patented LP3 Enzyme System naturally cleans, disinfects and removes ear exudate while destroying even the most resistant microbes. ZYMOX Otic’s advanced enzyme technology makes caring for a pet’s ears easy and fear-free with reduced touching of sensitive ears.  For use on any age dog, cat, exotics as well as those that are pregnant or lactating. Safe for extended use to manage or prevent.Made in the USA.UsesAcute and chronic otitisAntibacterial, antifungal, anti-yeastIrritated or inflamed earsRemoval of ear exudatePromotes healthy earsFor dogs, cats, small animalsPregnant or lactating female petsFor pets who swimPets who live in moist or hot environmentsFeaturesSoothingNon-toxicNo PRE-CLEANING of the earFear-free ear careEasy, once daily applicationNo antibioticsNo corticosteroidsAvailable sizes:  1.25 oz, 4 oz, 8 ozTo order, contact your preferred veterinary distributorManaging Bacterial ResistanceBiofilm producing infections are 10 to 100x more resistant to the effects of antimicrobial agentsWhat is Biofilm?Biofilm is an ill-defined mix of polysaccharides, nucleic acids and proteins encased in a slimy matrix created by microorganisms to house DNA. Biofilm is the believed to be a culprit for antibiotic resistance and the reason many otitis cases are persistent or recurring.  Due to incomplete killing of cells, bacteria can remain hidden in a complex biofilm even after the infection appears to be resolved, patiently waiting for ideal conditions to multiply and re-infect.How Advanced Formula ZYMOX PLUS Otic WorksThe Advanced Formula ZYMOX PLUS features the patented LP3 Enzyme System PLUS four additional enzymes.  The combination of mutanase, dextranase, cellulase, and betagluconase work to attack the complex biolfilm structure, prevent adhesion and metabolize its components.  When combined with the antimicrobial LP3 Enzyme System, the results are antibacterial and antifungal along with effective biofilm removal.Mutanase can exhibit diverse action pattern but fundamentally degrades ẞ-1, 3-glucan to glucose, making it water soluble.Dextranase is an enzyme which catalyzes the endohydrolysis of 1,6-a-glucosidic linkages in dextran resulting in damage to the biofilm.Cellulase is critical to an antibiofilm enzyme preparation, as cellulose is found in most biofilms. Cellulase has been shown to significantly reduce biofilm formation by the pathogen Pseudomonas aeruginosa.Beta glucanase is another important antibiofilm component that provides powerful anticandidal biofilm activity by lysing the glucans that are common in candida biofilms and compose up to 60% of fungal cell walls. Beta-glucan secreted by candida cells within biofilms significantly increase the organism’s resistance to antifungals and enzymatic breakdown of the beta-glucan can make candida more susceptible to destruction.